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Page 1
SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment.
Cancer Discov. 2023 Nov 1;13(11):2339-2355. doi: 10.1158/2159-8290.CD-23-0383.
Cancer Discov. 2023.
PMID: 37682219
Free PMC article.
Review.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
Taylor AM, Williams BR, Giordanetto F, Kelley EH, Lescarbeau A, Shortsleeves K, Tang Y, Walters WP, Arrazate A, Bowman C, Brophy E, Chan EW, Deshmukh G, Greisman JB, Hunsaker TL, Kipp DR, Saenz Lopez-Larrocha P, Maddalo D, Martin IJ, Maragakis P, Merchant M, Murcko M, Nisonoff H, Nguyen V, Nguyen V, Orozco O, Owen C, Pierce L, Schmidt M, Shaw DE, Smith S, Therrien E, Tran JC, Watters J, Waters NJ, Wilbur J, Willmore L.
Taylor AM, et al. Among authors: kelley eh.
J Med Chem. 2023 Oct 12;66(19):13384-13399. doi: 10.1021/acs.jmedchem.3c00483. Epub 2023 Sep 29.
J Med Chem. 2023.
PMID: 37774359
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Synthesis of the EFG Framework of Tamulamides A and B.
Kelley EH, Jamison TF.
Kelley EH, et al.
Org Lett. 2019 Oct 4;21(19):8027-8030. doi: 10.1021/acs.orglett.9b03015. Epub 2019 Sep 16.
Org Lett. 2019.
PMID: 31523969
Free PMC article.
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Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
Lim J, Kelley EH, Methot JL, Zhou H, Petrocchi A, Chen H, Hill SE, Hinton MC, Hruza A, Jung JO, Maclean JK, Mansueto M, Naumov GN, Philippar U, Raut S, Spacciapoli P, Sun D, Siliphaivanh P.
Lim J, et al. Among authors: kelley eh.
J Med Chem. 2016 Jul 14;59(13):6501-11. doi: 10.1021/acs.jmedchem.6b00708. Epub 2016 Jul 1.
J Med Chem. 2016.
PMID: 27329786
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Synthesis of the ABC framework of tamulamides A and B.
Kelley EH, Jamison TF.
Kelley EH, et al.
Bioorg Med Chem. 2018 Oct 15;26(19):5327-5335. doi: 10.1016/j.bmc.2018.04.046. Epub 2018 Apr 22.
Bioorg Med Chem. 2018.
PMID: 29729986
Free PMC article.
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